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This activates protein kinase A (PKA), which phosphorylates and stabilizes MITF (microphthalmia-associated transcription factor), driving transcriptional upregulation of tyrosinase, TRP-1, and TRP-2rate-limiting enzymes in the eumelanin biosynthesis pathway (Abdel-Malek et al., Pigment Cell Research, 2001)

Collagen, tissue, skin

Smith, N

Symptoms Many people who have uterine fibroids don't have any symptoms

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Available strengths include 0.25 mg, 0.5 mg, 1 mg, 1.7 mg, 2.4 mg and, where clinically suitable, 7.2 mg once weekly