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Drug companies have brought several to market as medications, including mainstay treatments for diabetes and weight loss

This approach aligns with diabetes management principles that emphasise individualised treatment based on patient characteristics, comorbidities, and treatment goals

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Cardiometabolic Research Beyond weight reduction, retatrutide's glucagon receptor component has attracted research interest for its cardiovascular effects

PMID: 36977352

However, a significant decrease in insulinotropic activity was observed with GIP in diabetic patient with hyperglycemia, whereas relatively preserved activity was noted with GLP-1 in the same patients (58), suggesting divergent effects of GIP and GLP-1 on -cells ( Figure 1 Section B)