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IDPM: PMC3060373

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13 In the SURPASS-4 trial (phase III), participants taking tirzepatide showed a much lower occurrence of composite kidney endpoint (time to first occurrence of eGFR decline of at least 40% from baseline, end-stage kidney disease, death due to kidney failure, or new onset albuminuria) compared with those who received insulin glargine (HR 0.58)

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Transcription of one of the PNAK2 mRNAs initiates from a different start site downstream of the major transcriptional start site and translation of the encoded protein begins from a non-AUG codon