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Denatured peptide molecules lose their biological activity
Following treatment medium was replaced and cell viability was assessed after 16 h (Naisbitt et al., 1998) by the resazurin reduction assay as described before (Sison-Young et al., 2017)
doi: 10.28996/2618-9801-2023-2-141-221 4 de BoerIHKhuntiKSaduskyTTuttleKRNeumillerJJRheeCMet al
46 High intratumoral expression of CYP3A4 can accelerate the metabolic inactivation of chemotherapeutic agents such as paclitaxel and docetaxel, thereby reducing local drug bioavailability, diminishing therapeutic efficacy, and ultimately contributing to drug resistance
26 Similarly, in adipose tissue, the accumulation of senescent cells contributes to insulin resistance and the development of metabolic disorders such as type 2 diabetes
10.1093/emboj/19.2.187 134 SilvaG
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