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WAT, White AT
10.1016/j.tibs.2014.02.002 28 HerzigS.ShawR
One of the star ingredients in this product is wild yam extract (or vegan phytomucin, as the company calls it)
By influencing the enzyme tyrosinase, which controls melanin synthesis, adequate glutathione levels may support more even skin tone and reduced oxidative discoloration contributing to overall skin clarity and brightness from within
Description 5-Amino-1MQ 5mg Research Grade Compound 5-Amino-1-methylquinolinium (5-Amino-1MQ) is a small molecule NNMT (nicotinamide N-methyltransferase) inhibitor that has attracted significant research interest for its role in cellular metabolism and adipogenesis pathways
This approach inspired other programmes: N-hexanoic-Tyr-D-Arg : enkephalin-derived, protease-resistant, studied for pain N-methyl-Aib inclusions : N-methyl substitutions increase membrane permeability at the cost of partial loss of receptor affinity Beta-peptides and D-amino acids : substitution of natural chiral residues by their D enantiomers, making the peptide invisible to endogenous proteases while (sometimes) preserving function Stapled peptides : hydrocarbon cyclisation, popularised by Verdine (Harvard), stabilises alpha helices and improves cellular penetration These strategies progressively shift the peptide / small molecule frontier
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