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It is essential to emphasise that patients with significant dyslipidaemia requiring substantial LDL cholesterol reduction should receive appropriate lipid-lowering therapy according to NICE guideline NG238
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Key pathways, including Wnt/-catenin, bone morphogenetic protein 2/Smad, phosphoinositide 3-kinase/Akt and protein kinase A, play a role in this
Plus, vitamin C can help fade existing pigmentation and prevent new dark spots from forming
Overall, as GLP-1RAs become increasingly prescribed, further pharmacovigilance studies are warranted, noted the authors
(4) Legros C, Devavry S, Caignard S, Tessier C, et al
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