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J Biol Chem 236:15341543 Turrens JF, Alexandre A, Lehninger AL (1985) Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria

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Given the reabsorption of renin by proximal tubule cells through megalin, and the broad expression of ACE within the kidney, allowing locally synthetized ANG II independent action, the interference of SGLT-2-i with intrarenal RAS could explain such results

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