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These medications can be incredibly helpful, but theyre not risk-free, especially during pregnancy. Dr South said it is good news that women who had accidentally become pregnant on the lower dose of semaglutide (Ozempic) had not seen any significant teratogenic effects in their babies
First, it is difficult for GLP-1 agonists to achieve anti-fibrosis effects because the major effect of GLP-1 agonists on MASH is likely to be indirect by extrahepatic path
Anti-inflammatory cytokine signalling investigation
Cited In Selenotranscriptome Network in Non-alcoholic Fatty Liver Disease (2021)
At baseline, MASH patients were different than no-MASH patients for: age 47 vs 42 y, AST 37 vs 22 IU/L, GGT 56 vs 29 IU/L, glucose 133 vs 98 mg/dL, steatosis 60% vs 20% and fibrosis 2 vs 0 ( p 3.25) or on liver stiffness measurement (LSM) 12.5 kPa on Fibroscan
