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Patients who are also optimizing hormonal status should be aware that sex hormones interact with MOTS-c signaling

And I said, Yes, you should be careful

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Unrestricted activation of endosomal TLRs (eTLRs) triggers inflammatory pathways, leading to a broad range of diseases and pathological processes, including rheumatoid arthritis (RA) 6,8 , systemic lupus erythematosus (SLE) 6,8,9 , juvenile idiopathic arthritis (JIA) 10,11 , autoimmune type 1 diabetes 12 and ischemiareperfusion injury 13

The animal evidence is consistent with the mechanistic findings