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IGF-1 LR3 (Long Arginine 3-IGF-1) is a synthetic 83-amino- acid peptide derivative of IGF-1 developed originally as a research tool, rather than as a therapeutic drug
However, the specific signaling pathways activated depend on the nature of the mechanical force applied, leading to distinct cellular responses
In the absence of circulating leukocytes, glial-derived interleukin-1 also disrupts the BBB (17)
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