Additionally, ERO1 has been shown to promote Ca 2+ release from the SR into the cytosol by regulating the IP3R and the RyR ( FIGURE 2 3 ERO1 and disease progression Under pathological conditions including hypoxia and metabolic disorders, dysregulated ERO1 expression is closely related to the occurrence and development of various diseases such as cancer (Wright et al., 2013), and inflammatory conditions (Song et al., 2008)
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Overall, this may lead to decreased adipose tissue and net energy consumption (i.e