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Neuropharmacology 50:917923 Imperato A, Ramacci MT, Angelucci L (1989) Acetyl-l-carnitine enhances acetylcholine release in the striatum and hippocampus of awake freely moving rats

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Additionally, for diabetic patients, the difficulty in managing blood sugar levels can lead to acute complications such as diabetic ketoacidosis (DKA) or hyperosmolar hyperglycemic state (HHS), both of which can be fatal if not promptly treated

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That is a major problem because concentration estimates are just that estimates generated by procedures neither designed nor validated to perform any measurement