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Egerton A, Brugger S, Raffin M, Barker GJ, Lythgoe DJ, McGuire PK, et al

On balance, any improvements in plasma homocysteine from moderate coffee consumption (approximately 150ml per day of the filtered preparation) may be due to a synergy of the beneficial polyphenols ingested at optimal dietary levels acting on biochemical pathways that are yet to be elucidated

Carracedo, A

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Updated guidance: Provider recommending transition to more effective option

The usual dose is 1000 mcg, but it might change based on how severe the deficiency is