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Because TG2 activity is highly associated with cellular redox status and alterations in the bidirectional flux of cellular thiol modulate TG2 activity, regulation of thiol flux in cells probably affects the TG2-mediated aggregation of the GST tag and its interaction with cellular proteins
This antioxidant activity helps prevent lipid peroxidationthe oxidative degradation of fatswhich can damage cell membranes and contribute to hepatocyte injury
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