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Our better understanding of the weight regulation mechanisms and the role of gut-brain axis on appetite has led to the development of safe and effective entero-pancreatic hormone-based treatments for obesity such as glucagon-like peptide-1 (GLP-1) receptor agonists (RA)

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Conversely, persistent diarrhoea or the presence of blood in stools warrants immediate medical assessment

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So, gel containing all the above used ingredients except glutathione was prepared and applied as placebo