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Due to its dual-agonist mechanism, it may be preferred for patients who need to lose a more significant amount of weight or have not achieved desired results with other treatments
However, semaglutide is FDA-approved with established long-term safety data, while retatrutide is still investigational
Mice were single-housed in cages equipped with a running wheel (23 cm in diameter, Techniplast)
Skin rashes or hives
Moreover, GLP-1RAs induced rapid weight loss may lead to supersaturation of the bile with cholesterol and hence increased incidence of gallstones formation [3, 4]
Semaglutide is also FDA approved for reducing cardiac risk in patients with Type 2 DM
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