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only 31.5% of the controls

Regarding the participants with MCI or AD, defined based on a clinical dementia rating (CDR) global score of 0.5 or 1, although the 18-month treatment with exenatide was safe and well-tolerated, it did not significantly affect clinical and cognitive measures, nor did it affect MRI cortical thickness and volume or most biomarkers in the cerebrospinal fluid (CSF), plasma, and plasma neuronal extracellular vesicles (EVs)

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Second, work with what is already approved

Semaglutide addresses it through multiple mechanisms: reduced caloric intake, improved insulin sensitivity, decreased de novo lipogenesis, and direct hepatoprotective effects

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