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Defective autophagy and AMPK inactivation drive ferroptosis in diabetic kidney disease

Journal of Biological Chemistry 267, 2227722281

Under physiological conditions, lactate indirectly regulates cellular antioxidant systems through modulation of the NAD(P)H/NAD(P)+ redox balance

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In one mouse study, researchers found that the peptide reduced the pain felt by the animals in their paws when placed on a mildly hot plate. The authors explained that this could be because GHK is similar in structure to cimetidine, a histamine H2 receptor antagonist sometimes given to reduce pain in certain digestive conditions.3 10 In rodents, doses as low as 0.5mg/kg were found to be effective in delivering these anti-pain effects.25 In a 70kg human, an equivalent dose would be around 5.6mg, though thats likely higher than necessary: pharmaceutical-grade GHK-Cu normally ranges from 0.5 mg to 2.5mg per injection

Healthcare providers are encouraged to report any suspected adverse events, including mental health changes, through the FDA's MedWatch program