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The Bcl-2/Bax ratio increased and cleaved caspase-3 levels dropped, indicating reduced apoptosis (Pyo et al., 2007)

doi: 10.1016/j.cmet.2012.04.023 51 HrholdFEiselDOswaldMKolteARllDOsenWet al

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Future research may focus on further exploring the structureactivity relationship of NRF2 activators, identifying more effective and selective compounds, and studying the potential therapeutic applications of these activators in different disease models

The doses may be uneven doses with regard to one another or with regard to the individual components at different administration times

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