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The TIP3P water model was used to solvate the protein-ligand complex in a rectangular box with periodic boundary conditions and a minimum distance between the solute and the box of 10

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Amylin analogs like cagrilintide appear to act via hindbrain satiety circuits and may also influence reward-related pathways involving AgRP and POMC neurons

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Martins GF, Siqueira Filho AG, Santos JB, Assuncao CR, Vieira FB, Valencia A, et al

However, based on current research data, metabolic factors cannot be ruled out as potential contributing factors