Leyden J., Stephens T., Finkey M., Appa Y., Barkovic S
The right choice depends on whether the injury is discrete and localized or diffuse and multi-site
Patients who report constipation starting in weeks 1-4 fall into two groups by week 6: Group 1 (adapters, ~65% of those with early constipation): Bowel movement frequency has stabilized or started improving by week 6
Handling Notes Do not freeze once reconstituted
They work through different mechanisms and can produce synergistic effects
Handling and Storage Recommendations Store unopened vials at 28 C, with 20 C recommended for long-term storage Protect from light and moisture After reconstitution, store solutions at 28 C and use within laboratory-defined timeframes Avoid repeated freeze-thaw cycles Follow standard laboratory safety, labeling, and handling procedures All handling and storage are carried out within laboratory research environments