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To improve drug propertiessuch as stability and anticancer activityof diazeniumdiolate-based NO donors, a number of new molecules were synthesized and biologicaly evaluated 109,125,126

E&OE The author was formerly executive director of Indian Journal of Clinical Practice in an era when there were only JAMA and BMJ as the leading medical journals available for Indian clinicians

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Method: Sprinkle the gelatin across the surface of the water

Initial dosing starts at 2.5 mg weekly to improve tolerability and is titrated every 4 weeks in 2.5 mg increments to a maximum of 15 mg, providing six dosing options: 2.5 mg 5 mg 7.5 mg 10 mg 12.5 mg 15 mg The initial low dose is not intended as the full therapeutic dose, but to reduce gastrointestinal side effects while patients adapt