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It works by stimulating insulin secretion in a glucose-dependent manner, suppressing glucagon release, slowing gastric emptying, andcrucially for weight lossreducing appetite through effects on brain centres that regulate hunger

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Efficacy and safety of once-weekly semaglutide versus daily canagliflozin as add-on to metformin in patients with type 2 diabetes (SUSTAIN 8): a double-blind, phase 3b, randomised controlled trial

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