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UGTs: UDP-glycosyltransferases

The most commonly reported side effects of retatrutide in clinical trials are gastrointestinal, including nausea, vomiting, diarrhoea, constipation, and decreased appetite, consistent with other GLP-1-based therapies

Over time, this creates a not-so-fun feedback loop: harder stools more straining tighter pelvic floor even harder stools

Summary: Microdosing GLP-1 for Hashimoto's is an unapproved, off-label practice lacking clinical evidence, and the NHS does not recommend GLP-1 receptor agonists for thyroid conditions without concurrent type 2 diabetes or obesity meeting specific criteria