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Tolerability Differences Tirzepatide may carry somewhat higher gastrointestinal event rates at equivalent steps, possibly because the GIP pathway affects gut motility differently

Regul Pept (2014) 190-191:111

They projected that based on the known weight-loss and cardiovascular risk factor effects of this therapy that its use could result in 55 million fewer people with obesity and prevent up to 2 million heart attacks, strokes and other adverse cardiovascular events over 10 years

E., La, K., Erlandson, K

The key strategies for minimizing regain during a short break include maintaining a high protein intake of 1.6-2.2 grams per kilogram of body weight daily, continuing or increasing resistance training to preserve muscle mass, planning meals in advance so hunger does not drive impulsive food choices, monitoring weight weekly but not daily to avoid overreacting to normal fluctuations, and staying hydrated since the body may retain more water without GLP-1 mediated effects on fluid balance