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In placental tissues obtained from offspring of obese parents, DNA hypermethylation dysregulated the expression of histone deacetylase 4, (HDAC4), which modulates fat cell expansion, promotes energy utilization and protects from excessive weight gain [174,175,176,177] This dysregulation could elevate metabolic disease risk in offspring later in life [174]
Olsson JM Show more Staff and contact Group leader All members of the group Visiting address Karolinska Institutet, NVS, Neurogeriatrik, Akademiska Strket 1, Solna, 171 64, Sweden Postal address Karolinska Institutet, NVS, Neurogeriatrik, Visionsgatan 4, J9:20, Solna, 171 64, Sweden
Among the most promising developments are two medications: Survodutide and Tirzepatide
But drinking regularly and to excess of course will cause health consequences and regular excess consumption can lead to absorption problems with B12 and other nutrients
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