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B12 acts as a cofactor for key enzymes, particularly methionine synthase and methylmalonyl-CoA mutase, which facilitate essential biochemical reactions involved in DNA synthesis, red blood cell formation, and neurological function

News Release: Tirzepatide significantly reduced A1C and body weight in people with type 2 diabetes in two phase 3 trials from Lilly's SURPASS program

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It does not slot neatly into an endocrine signaling cascade

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Oral supplements , including tablets and capsules, are also widely used for maintenance and gradual improvement, although they typically have lower bioavailability