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It is characterized by exaggerated secretion of glucagon-like peptide-1 (GLP-1), dysregulated secretion of insulin, and a rapid drop in blood sugar

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20,21 EMPA-REG OUTCOME was not designed to capture amputation risk, so there is currently no head-to-head comparison of amputation risk with empagliflozin versus canagliflozin, and such interpretation is likely not possible owing to multiple factors confounding any comparison between trials

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