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doi: 10.1111/j.1365-2621.2005.01091.x 93
RBP-J then transcriptionally enhances TRIM59 expression, forming a feedforward loop that drives gemcitabine resistance
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Clinical trials in humans are needed to confirm efficacy and long-term safety
For these individuals, vitamin B12 injections are often the most effective way to restore healthy B12 levels because they bypass the digestive system entirely, delivering the vitamin directly into the bloodstream for maximum absorption (around 95% compared to 25-50% for oral supplements)
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