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Antiplatelets: These include medications like aspirin or Plavix, which prevent blood cells called platelets from sticking together

Given that GLP-1 RAs result in weight loss and the pronounced effects of weight loss on haemodynamic disturbance and cardiac reverse remodelling in obese HF patients, the question is, to what extent is the effect of the drugs related to a direct effect on the cardiovascular system in HF

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However, evidence regarding specific effects on sugar versus fat cravings is still developing, and individual responses vary considerably

Among them, retatrutide has shown significant clinical advantages in phase II clinical trials, reducing the weight of obese patients by up to 24.2% in 48 weeks and lowering the HbA1c of type 2 diabetes patients by 2.2% in 36 weeks ( 3.3.2 Regulation of hepatic lipid metabolism Triple receptor agonists exhibit promising synergistic effects on hepatic lipid metabolism, a central pathological feature in MASLD

Notably, the observed reductions in the odds of substance use disorders, including a 74% decrease in the odds of AUD, a 69% reduction for OUD, a 68% reduction for NUD, and a 75% reduction for CUD, among GLP-1 RA users were consistent with emerging preclinical and clinical studies showing that GLP-1 RA modulates reward pathways in the brain to reduce SUD (17, 23)