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There is zero receptor overlap, meaning both compounds can work at full efficacy without interfering with each other

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A previous study has shown that HD could effectively play a role in fighting against immunological liver injury induced by concanavalin A through the reduction serum levels of ALT and AST, the content of MDA in liver homogenates and the hepatic caspase-3 activity and TNF- level (Suresh et al., 2014)

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In our research, we observed that the reduction in tight junction proteins and mucin due to IIRI was significantly reversed by metformin