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Acknowledgements The author would like to express his deepest gratitude to the Board of Trustees of Delta University for Science and Technology for their continuous guidance, encouragement, and support throughout the course of this research

FIGURE 2 4 Discussion 4.1 Evolutionary patterns of antioxidase-related genes in hypoxia-tolerant lineages Hypoxia-tolerant mammals have evolved adaptive mechanisms, including oxygen binding, storage and transportation capacities ( SOD was also identified in cetaceans ( GST genes in divergent taxonomic groups, which is indicative of pervasive adaptive evolution ( min = 0.062 for GPX2 , max = 0.261 for SOD1 ), indicating that purifying selection played an important role in maintaining their function of antioxidase-related genes

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