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reported that metformin regulates ferroptosis through the SIRT3/AMPK/mTOR pathway to improve weight, metabolic disorders, and ovarian dysfunction in PCOS mice (173)

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458 Specifically, in response to Frataxin deficiency, the activation of iron-responsive element binding protein 1 (Fe-S protein) increases cellular iron uptake, with the iron being translocated into mitochondria via mitochondrial iron transporters in an attempt to compensate for impaired Fe-S cluster biogenesis

By modulating the release of certain neurotransmitters, DSIP can influence sleep patterns, particularly promoting slow-wave sleep, the most restorative stage of sleep

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