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However, it causes mast cells to release more histamine while inhibiting the DAO enzyme, which breaks down histamine, especially in your gut and uterus

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During the luteal phase, particularly 5-7 days before menstruation, antihistamines like loratadine and famotidine can be effective in managing the histamine reaction that contributes to skin irritation and rashes

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The authors proposed that folate depletion may cause impairment of cell division and expansion, resulting into this root phenotype