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A 2025 systematic review in the HSS Journal identified 36 studies from 1993 to 2024, with consistent findings across multiple animal models and injury types

Worse, the risk of death was 157% higher for women with high dietary calcium intake who also took a calcium supplement

However, this typically only occurs if the greying was specifically caused by B12 deficiency

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In a 26-week phase 2 trial involving individuals without diabetes, it was evaluated at doses ranging from 0.3 mg to 4.5 mg per week

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