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After entering the bloodstream via the intestine, dietary polyphenols undergo enterohepatic circulation and, to a lesser extent, renal metabolism, and are bio-transformed several times until they are excreted in bile and urine

N., Williams, K., Phillips, H., Shaffer, J., Beaver, L

First, though, lets cover how your genes interact with estrogen metabolism (phase I and phase II) and how your genes impact estrogen creation

The most consistently reported pathway involves VEGFR2 and the Akt-eNOS nitric oxide cascade