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Nauck M, Stockmann F, Ebert R, Creutzfeldt W (1986) Reduced incretin effect in type 2 (non-insulin-dependent) diabetes

Because treating any chronic disease requires more than a quick-fix medication

Primary endpoints covered percent change in body weight and change in WOMAC pain score

Right away, there was a realization that something that stimulates insulin secretion could be used for the treatment of diabetes. Subscribe to The Pulse He said scientists at the time were trying to make a human diabetes treatment based on GLP-1, but it was difficult because humans would break down the hormone, or would get sick if they got too much of it too quickly

Advanced age, hypertension, dyslipidemia, and diabetes are recognized risk factors for CKD (Table 5)

doi:10.1016/S0140-6736(23)01053-X 3