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doi: 10.4049/jimmunol.1602110 59 JainS.NarwalM.Omair AnwarM.PrakashN.MohmmedA

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235 A notable positive feedback loop amplifies TGF- signaling: TGF--induced Smad2/3 activation upregulates TGFBRAP1, which competitively binds TRI and prevents its degradation by Smurf1/2-mediated ubiquitination