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Early clinical trials have shown promising weight-loss results, but it's important to understand that retatrutide remains investigational and has not yet received FDA approval

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The mechanistic explanation is not speculative: the glucagon receptor adds hepatic fatty-acid oxidation, adipose lipolysis and thermogenic energy expenditure that dual agonism cannot engage by design 27, and the Phase 2a MASLD readouts 8590% liver-fat reduction is a direct signature of that pathway 3