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The study found that high glucose-induced loss of PCBP1 activates the HIF-1/HO-1 pathway, leading to intracellular iron homeostasis imbalance and increased ferrous ion levels, while also exacerbating lipid peroxidation and ferroptosis

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doi:10.1371/journal.pone.0033944 Lederman RJ, Mendelsohn FO, Anderson RD, Saucedo JF, Tenaglia AN, Hermiller JB, Hillegass WB, Rocha-Singh K, Moon TE, Whitehouse MJ et al (2002) Therapeutic angiogenesis with recombinant fibroblast growth factor-2 for intermittent claudication (the TRAFFIC study): a randomised trial

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