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As expected, hepsin / mice displayed heightened oxidative stress after APAP exposure compared to wild-type mice, indicated by a significant decrease in GSH and an increase in nitrotyrosine levels, leading to more severe liver damage and mortality

A has a neurotoxic effect, which can lead to neuronal degeneration, death, apoptosis, and decrease in the number of synapses and ultimately lead to cognitive impairment and behavioral abnormalities (Ye et al., 2021)