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6.10.4 Therapeutic strategies 6.10.4.1 Small molecules One study has proven that a potent ALK5 inhibitor, namely SB431542, can inhibit related molecules, such as TGF-, Smad3, Smad2, and a-SMA, and upregulates anti-fibrotic factor MMP2 in rats with DHEA-induced PCOS, thereby mitigating ovarian fibrosis via the TGF-/Smads signaling pathway (283)
N-Acetylcystein (NAC)
The drug was also found to slow down the progression of kidney disease in such patients (Marso, Daniels, Brown-Frandsen)
It is estimated that the prevalence of diagnosed NASH will reach 18 million by 2027 in US, Japan, and EU 5 (England, France, Germany, Italy, and Spain)
Other micronutrients including zinc, copper, and vitamin A contribute to tissue repair in various ways
Free T4 (Thyroxine): This is the "storage" version of the hormone produced by your thyroid
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