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Patients were eligible if they had left ventricular ejection fraction (LVEF) 45%, NYHA functional class IIIV, BMI 30 kg m 2 , KCCQ-CSS 35 mmHg

The concept was that if tirzepatide could be shown to be noninferior to dulaglutide, one could reasonably infer that tirzepatide carries the same protective effect dulaglutide showed in REWIND

What trials do show is that higher doses are linked to stronger side effects, especially digestive ones

It improves blood flow, enhances oxygen and nutrient delivery to muscles, supports cardiovascular health, and may even boost exercise performance and recovery

Pineal melatonin levels then surge to a peak in the middle of the night (around 24 a.m