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The aggressive titration tail in the 12 mg arm of the Phase 2 trial was strongly associated with higher rates of transient gastrointestinal adverse events, which is why researchers generally favor slower escalation when tolerability is prioritized

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Avoid high-fat and fried foods, especially in the hours after injection

Compounded Semaglutide: According to the company, starting at approximately $159 per month as of March 2026