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However Lillys demonstration that a GIP/GLP-1 receptor co-agonist (tirzepatide) has superior efficacy compared to selective GLP-1 receptor agonists, has renewed interest in the first incretin. Lilly rolled out their SURPASS trials to position their agent amongst existing diabetes medications and GLP-1 agonists

Ganoderma lucidum polysaccharides ameliorated depression-like behaviors in the chronic social defeat stress depression model via modulation of Dectin-1 and the innate immune system

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These observations, combined with our findings of enhanced ATP signalling in the presence of Exendin-4 in the human DRG neurons, and by others in rodent neurons [31], suggest that GLP-1R may participate in modulating gut motility, rather than pain signalling

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