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Key findings include: Upregulation of VEGFR2 expression and internalization in endothelial cells Activation of the VEGFR2-Akt-eNOS signaling cascade Enhanced endothelial cell proliferation and tube formation Improved collateral circulation in ischemic injury models The peptides pro-angiogenic effects appear particularly relevant in healing scenarios where blood supply restoration is critical for tissue recovery

Townsend DM, Shen H, Staros AL, Gat L, Tew KD

Some sources suggest that freezing reconstituted peptide solution can damage the molecular structure through ice crystal formation

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