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We also summarize newly proposed mechanisms associated with hepatoprotection and tumor suppression, such as attenuation of hepatocellular stress through inhibition of the NEDD9/FAK/AKT cascade and a potential role in cell-cycle regulation via the HDAC/p21 axisalthough the latter remains to be validated in MASLD-specific models
The most important results from the clinical studies involving danuglipron are shown in Table 1
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Excessive mTOR activity has been shown to be associated with the pathophysiology of cognitive deficits
Chaperone-mediated autophagy degrades Keap1 and promotes Nrf2-mediated antioxidative response
Between 2017 and 2022, there were 5,713 single-substance exposure cases reported to U.S
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