There are multiple publications evaluating 24hour urines of those on GLP1 medications compared to those not taking the medication, and they show overall no increased risks, he said
The amount of GLP-1 in weight loss injections is so much more than your body produces on its own, so it can help you overcome that resistance while youre on the medication, Messer notes

This action makes these agents a therapeutic option for weight loss.56 Although to a lesser extent, delay in gastric emptying contributes to the anorexigenic effect.61 Clinical trials conducted with GLP-1 receptor agonists in patients with obesity (or excess weight [BMI 27] with comorbidities), or with DT2 and excess weight or obesity, have achieved weight reductions greater than those reported for orlistat, as well as those observed with oral antidiabetic agents such as the sodium glucose type 2 cotransporter inhibitors (SGLT2i) or metformin.62 In a meta-analysis of more than 10 000 patients with obesity, those treated with GLP-1 receptor agonists lost, on average, 7kg more than those in the control group.63 Weight loss of up to 15% has been observed after 12 months of treatment,64,65 a level that had only been achieved through surgical methods
By the time patients reach the maintenance dose of 2.4mg for weight management, GI symptoms are at their peak frequency
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2016;12(7):S157