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Harper AR, Nayee S, Topol EJ
For the separate question of whether the sleep effect holds up at all as distinct from this articles question of what was dosed see our companion review, does DSIP improve sleep in the research literature
Weeks 8-12 : More significant improvements in deeper wrinkles, continued collagen density increase, improved skin thickness (measured via ultrasound in clinical settings), and sustained reduction in age-related skin laxity
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Additionally, variations in dosing equivalence, species-specific GLP-1 receptor expression, and metabolic responsiveness further complicate the direct translation of these findings to human diseases (De Giorgi et al., 2025)