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It has been demonstrated that ligand-activated GLP- 1 receptor interacts with the Gas subunit and activates adenylate cyclase to generate cAMP

10.2337/diacare.26.12.3215 6

Switch to a different GLP-1 agonist like semaglutide , which some people tolerate better

Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M

GLP-1s can result in considerable weight reduction, with individuals experiencing an average loss of 10-20% of their total body weight

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